Reishi Research

Key Research on Reishi Mushroom Medicinal Extract

1. Immune System Support

Reishi mushrooms contain bioactive compounds such as polysaccharides and triterpenoids, which have demonstrated immune-enhancing effects. Studies indicate that Reishi can affect the genes in white blood cells, which are critical parts of your immune system. Research suggests that Reishi mushrooms could help manage the function of T lymphocyte cells (T cells), which play an important role in immunity, such as fighting against infections and cancer. Healthline

2. Anti-Cancer Properties

Several test-tube and animal studies have shown that Reishi extract may lead to the death of cancer cells. Some research has also investigated whether Reishi could be beneficial for prostate and colorectal cancer due to its effects on inflammation and certain signaling pathways involved in cancer development. A 2016 review indicated that the mushroom could benefit people with cancer when used alongside traditional treatment by increasing the activity of white blood cells and improving quality of life. Healthline

3. Fatigue and Depression Reduction

Reishi mushrooms may help reduce fatigue and depression. According to the authors of a 2024 review, one study found that the polysaccharides in Reishi mushrooms may help decrease fatigue after exercising. Another 2024 study in people with cancer found that taking Reishi mushroom products helped reduce fatigue, anxiety, and depression. While Reishi mushrooms may be promising for people with certain conditions, it's unclear if they would benefit people without these conditions. Healthline

4. Heart Health

Studies examining in vitro studies and in vivo animal models found that Reishi mushrooms may help decrease blood sugar and triglycerides and increase HDL “good” cholesterol. At least one older study in healthy adults showed a slight trend toward lower lipid levels, but this was not statistically significant. That said, more recent research suggests that Reishi supplementation helped decrease cholesterol levels and manage triglycerides and other lipid markers. Healthline

5. Blood Sugar Management

Some animal studies suggest that certain compounds found in the Reishi mushroom may help decrease blood sugar. On the other hand, a 2016 study in humans found no effect of Reishi supplementation on fasting blood sugar or hemoglobin A1c, a marker of long-term blood sugar management. Therefore, more research is needed here as well. Healthline

 

Reishi Mushroom: A Medicinal Overview

Scientific Name: Ganoderma lucidum

Common Names: Reishi, Lingzhi, Mannentake

Appearance: Reishi mushrooms have a distinctive, reddish-brown, varnished appearance with a kidney-shaped cap. They typically grow on decaying hardwood trees in hot and humid climates.Wikipedia+1Wikipedia+1

Traditional Use: Reishi mushrooms have been used in traditional Chinese medicine for over 2,000 years to promote health and longevity.

 Bioactive Compounds

  • Polysaccharides (e.g., Beta-glucans): Known for their immune-boosting properties.

  • Triterpenoids: Compounds with potential anti-inflammatory and anticancer benefits.

  • Ganoderic Acids: Steroid-like compounds that may contribute to cardiovascular health.

Health Benefits

  • Immune System Enhancement: Beta-glucans in Reishi mushrooms activate immune cells, strengthening the body's defense mechanisms.Wikipedia

  • Cancer Support: Reishi extracts may inhibit tumor growth and enhance the effects of chemotherapy drugs.

  • Fatigue and Depression Reduction: Reishi mushrooms may help reduce fatigue and depression, particularly in individuals with specific health conditions.Healthline

  • Heart Health: Reishi mushrooms may help decrease blood sugar and triglycerides and increase HDL “good” cholesterol.Healthline

  • Blood Sugar Management: Certain compounds in Reishi mushrooms may help decrease blood sugar levels.

Safety Considerations

  • Allergic Reactions: Some individuals may experience allergic reactions to Reishi mushrooms.

  • Drug Interactions: Reishi mushrooms may interact with certain medications, including anticoagulants and hypoglycemic drugs.

  • Pregnancy and Breastfeeding: Consult a healthcare provider before using Reishi mushrooms during pregnancy or breastfeeding.

  • Liver Health: Long-term use of powdered Reishi mushrooms may cause liver damage.